Nonalcoholic fatty liver disease is a heterogeneous disorder characterized by liver steatosis;
inflammation and fibrosis are features of the progressive form nonalcoholic steatohepatitis.
The endoplasmic reticulum stress response is postulated to play a role in the pathogenesis
of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. In particular, C/EBP
homologous protein (CHOP) is undetectable under normal conditions but is induced by
cellular stress, including endoplasmic reticulum stress. Chop wild type (Chop+/+) and knock …