[HTML][HTML] Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1 …
CYP2E1 is recognized as the most important enzyme for initiation of acetaminophen (APAP)-
induced toxicity. In this study, the resistance of Cyp2e1-null mice to APAP treatment was
confirmed by comparing serum aminotransferase activities and blood urea nitrogen levels in
wild-type and Cyp2e1-null mice. However, unexpectedly, profiling of major known APAP
metabolites in urine and serum revealed that the contribution of CYP2E1 to APAP
metabolism decreased with increasing APAP doses administered. Measurement of hepatic …
induced toxicity. In this study, the resistance of Cyp2e1-null mice to APAP treatment was
confirmed by comparing serum aminotransferase activities and blood urea nitrogen levels in
wild-type and Cyp2e1-null mice. However, unexpectedly, profiling of major known APAP
metabolites in urine and serum revealed that the contribution of CYP2E1 to APAP
metabolism decreased with increasing APAP doses administered. Measurement of hepatic …
