The molecular toxicology of acetaminophen
P David Josephy - Drug metabolism reviews, 2005 - Taylor & Francis
Drug metabolism reviews, 2005•Taylor & Francis
The history of the development of the analgestic drug acetaminophen is reviewed with an
emphasis on the characteristics of its overdose toxicity. The P450-catalyzed oxidation of
acetaminophen generates a reactive electrophile that binds covalently to proteins.
Involvement of specific P450 enzymes in acetaminophen toxicity can be probed by
experiments with knock-out mice. The identification of specific target proteins may help to
clarify the mechanism of acetaminophen hepatoxocity.
emphasis on the characteristics of its overdose toxicity. The P450-catalyzed oxidation of
acetaminophen generates a reactive electrophile that binds covalently to proteins.
Involvement of specific P450 enzymes in acetaminophen toxicity can be probed by
experiments with knock-out mice. The identification of specific target proteins may help to
clarify the mechanism of acetaminophen hepatoxocity.
The history of the development of the analgestic drug acetaminophen is reviewed with an emphasis on the characteristics of its overdose toxicity. The P450-catalyzed oxidation of acetaminophen generates a reactive electrophile that binds covalently to proteins. Involvement of specific P450 enzymes in acetaminophen toxicity can be probed by experiments with knock-out mice. The identification of specific target proteins may help to clarify the mechanism of acetaminophen hepatoxocity.
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